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🔑 Key Takeaways

  1. LPA levels, a genetic risk factor for vascular disease, cannot be easily modified by lifestyle changes or medications. Testing for LPA once can influence treatment and further tests, while certain interventions may help lower levels for some individuals.
  2. Taking care of gut health and reducing inflammation through diet and supplementation may decrease the risk of dementia and Alzheimer's disease, particularly for those with the APOE4 gene variation.

📝 Podcast Summary

LPA: A Genetic Risk Factor for Vascular Disease

Lipoprotein little A (LPA) is a risk factor for vascular disease, including heart disease and stroke. It is largely genetic and difficult to modify with lifestyle changes, supplements, or medications. Testing for LPA usually occurs once, and if it is high, it influences how a person is treated and further tests that are conducted. While niacin, coq 10, and red yeast rice may help lower LPA levels for some individuals, for others, these interventions may not make a significant difference. Statins are not effective in lowering LPA and may even increase it. Hormonal shifts, such as menopause and thyroid disorders, may cause LPA levels to rise, but certain hormone therapies could potentially lower them.

Gut Health and Alzheimer's Disease: The Inflammation Connection

There is a connection between gut health and Alzheimer's disease. When looking at it from a functional medicine approach, inflammation in the body, which can be triggered by an imbalanced gut, can contribute to dementia or Alzheimer's disease. While there may not be specific research showing a connection between methane dominant SIBO and Alzheimer's, anything that increases inflammation in the body could increase the risk for dementia. It's important to note that everyone's risk factors and genetics are different, so the impact may vary. For individuals with the APOE4 gene variation, which is associated with an increased risk for dementia, following a diet similar to the Mediterranean diet, known as the mind diet, rich in Omega-3 fats and phytonutrients, may help lower their risk. Maintaining high levels of Omega-3 fats through proper supplementation is also recommended.