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    How to Lose Fat with Science-Based Tools

    Engage in novel types of movements during exercise such as HIIT, SIT, and MICT to mobilize stubborn body fat pads. Choose exercise based on personal preference and goals.

    enMay 24, 2021

    About this Episode

    This episode I describe the science of fat loss, including how fat is mobilized and oxidized (burned) and how to increase fat burning by leveraging the nervous system. Most people don't realize it, but our neurons connect to our fat and release epinephrine/adrenaline to facilitate fat oxidation. Access the full show notes, including referenced articles, resources and more at hubermanlab.com. Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman LMNT: https://drinklmnt.com/huberman Waking Up: https://www.wakingup.com/huberman Momentous: https://www.livemomentous.com/huberman Timestamps (00:00:00) Introduction  (00:00:31) Sponsors: AG1, LMNT & Waking Up (00:06:00) Fat Loss: The Key Role of Neurons  (00:08:44) The First Law of Fat Loss  (00:11:00) Neurons Connect To Fat! (& That Really Matters)  (00:13:38) 5 Pillars of Metabolism: Sleep, Essential Fatty Acids, Glutamine, Microbiome, Thyroid  (00:19:20) Mindset Truly Matters: Amazing Examples of Beliefs on Fat Loss  (00:23:08) Our Brain Talks To Our Fat (00:25:00) The Most Incredible & Dangerous Fat Loss Agent  (00:27:28) Losing Fat Is a Two-Part Process: Mobilization and Oxidation   (00:32:25) The Critical Role of Adrenaline/Epinephrine, But NOT from Adrenal Glands  (00:34:45) Fidgeting & Shivering: A Powerful Science-Supported Method For Fat Loss  (00:41:24) How Fidgeting Works: Promotes Epinephrine Release into Fat. “N-E-A-T”  (00:44:55) Two Ways of Using Shivering To Accelerate Fat Loss   (00:47:30) White, Brown & Beige Fat; & Using Cold-Induced Shiver To Burn Fat  (00:50:25) How To Use Cold Properly To Stimulate Fat Loss: Succinate Release Is Key/Shiver  (00:52:26) Exact Protocols: (1-5X per week); Don’t Adapt! Submerge and Exit “Sets & Reps”  (00:56:15) thecoldplunge.com see “protocols” tab Cold-Shiver-Fat-Loss Tool (cost free)  (00:58:03) If Fat-Loss Is Your Goal, Avoid Cold Adaptation: Remember Polar Bear Swimmers   (00:58:17) Irisin: Underwhelming; Succinate Is The Real Deal  (01:00:00) Brown Fat, Why Babies Can’t Shiver and Becoming a Hotter Furnace, Adding Heat  (01:01:55) Ice On Back of The Neck, Cold Underpants: Not A Great Idea For Fat Loss  (01:04:00) A Key Paper For the Aficionados: www.ncbi.nlm.nih.gov/pmc/articles/PMC2826518/  (01:05:00) Spot Reduction: There May Be Hope After All. Targeting Specific Fat Pads.  (01:09:20) Exercising For Fat Loss: What Is Best? High Intensity, Sprinting, Moderate Intensity?   (01:13:30) Exercising Fasted: Does It Truly Accelerate Fat Loss/Oxidation.   (01:16:30) The 90 Minute Rule: After 90 Minutes, The Fasted Exercisers Start To Burn More Fat  (01:18:15) If High-Intensity Training Is Done First, The Benefits of Fasting Arrive Before 90min.  (01:22:44) Post-Exercise Metabolic Increases: How To Bias This Toward Fat Oxidation  (01:26:05) A Protocol For Exercise-Induced Fat Loss; Adrenalin Is The Effector  (01:28:50) Supplements/Compounds For Fat Loss Part: Caffeine Fidgeting, & Caffeine Adaptation  (01:34:30) Ephedrine, Fenfluramine: Removed From Market Due to Safety Concerns  (01:35:22) GLP1 (Glucagon-Like Peptide 1), Yerba Mate, Guayusa Tea, Semaglutide   (01:40:30) Berberine, Metformin: Glucose/Insulin Reduction, Increase Fat Oxidation: But Caution  (01:41:28) Gardner Lab Results: What You Eat May Not Matter, But Adherence Is Key Tool  (01:43:00) examine.com & Enter “Yerba Mate”: Lowers Heart Rate Even Though Is a Stimulant  (01:44:35) Acetly-L-Carnitine: Facilitates Fat Oxidation  (01:48:00) Summary List of Tools & How Nervous System Controls Fat Loss  (01:51:20) Cost Free & Other Ways To Support Our Podcast, Making Sure We See Feedback  Title Card Photo Credit: Mike Blabac Disclaimer

    🔑 Key Takeaways

    • The nervous system collaborates with cells to promote fat loss. Hormones, thermogenic mil, and metabolism impact calories burned. Using science-based tools like cold exposure and activating brown/beige fat will accelerate fat loss.
    • Prioritize quality sleep, consume essential fatty acids from fatty fish and grass-fed meats, satisfy sugar cravings with glutamine and amino acid-rich foods like cottage cheese, and incorporate Brazil nuts for selenium to support thyroid function and metabolism for better fat loss results.
    • Ingesting fermented foods daily supports the gut microbiome and thyroid hormone with probiotics, iodine, and selenium. Belief effects play a significant role in weight and fat loss, and a balanced approach uses quality science and physiology to increase fat loss rates.
    • Understanding how your nervous system controls your body's thermogenic environment and utilizing methods like fat mobilization and oxidation can help you effectively burn more fat without resorting to dangerous compounds like DNP.
    • To burn fat, it's important to activate your nervous system through movement. Subtle movements like shivering and neuron-activating exercises like yoga and pilates can promote more fat liberation and oxidation. It's not just about calorie deficit, but also nervous system activation.
    • Fidgeting throughout the day, even in subtle ways, can help burn extra calories and aid in weight loss goals, which can be particularly helpful for those who are time-limited or not yet ready to embrace regular exercise.
    • Simple movements like fidgeting, standing up, and pacing release epinephrine that burns calories through Non-Exercise Activity Thermogenesis (NEAT). Shivering and cold exposure can also trigger fat loss through oxidation of fatty acids and brown fat activation.
    • Cold exposure through taking cold showers or ice baths 1-5 times a week can increase brown fat thermogenesis and fat burning by triggering the release of Ate S U C C I N a T E, resulting in more calorie burn. However, consult a doctor before attempting to avoid hypothermia and heart shock.
    • Gradually increasing cold exposure can stimulate brown fat thermogenesis, leading to fat loss and other health benefits such as reduced inflammation. Key is to reach the shiver point and avoid building up tolerance too quickly.
    • Gradually increasing exposure to cold environments and timing/types of exercises can boost metabolism and fat loss through brown fat and neural innovation. Spot reduction remains unproven but intriguing for further research.
    • Engage in novel types of movements during exercise such as HIIT, SIT, and MICT to mobilize stubborn body fat pads. Choose exercise based on personal preference and goals.
    • Mix up your workout routine with interval training and moderate continuous training to maximize cardiovascular benefits and fat oxidation, while considering individual factors and goals.
    • High intensity exercise for 20 to 60 minutes, followed by medium intensity exercise, with low insulin levels, can burn more body fat. Depleting glycogen before steady state exercise is crucial for optimal results.
    • A combination of high intensity training followed by moderate to low intensity training is the best way to burn fat. Engaging in regular exercise that you enjoy is crucial for long-term success.
    • Caffeine can aid in burning fat and improving exercise results, but it must be consumed within safe dosages and is not a substitute for healthy behavior modifications. Always prioritize the science and incorporate exercise for optimal cardiovascular health.
    • Drinking mate tea prior to exercise can help burn more fat, and reusing mate tea leaves can increase its benefits. Gua tea is a sweeter alternative that also triggers fat burning. However, prescription drugs should not be taken without a doctor's guidance.
    • Lowering insulin levels through diet and compounds like burberine, Metformin, carnitine, Ma Gua, GLP one and Acetyl L Carnitine can increase fat oxidation. Adherence to a low or moderate carbohydrate diet is important to achieve this goal. Find a diet that works for you and is healthy.
    • Supplementing with LCD L-carnitine may improve cellular metabolism, reduce inflammation, and improve fertility. While not necessary for fat loss, other methods include increasing caloric burn through exercise and utilizing the GLP one pathway through certain compounds.

    📝 Podcast Summary

    Science-Based Tools to Accelerate Fat Loss

    Fat loss is governed by the nervous system and its collaboration with cells like Lia and macrophages, which can encourage accelerated fat loss. It's important to acknowledge the calories in versus calories out formula, but the calories burned portion is strongly influenced by factors including hormones, thermogenic mil, metabolism, and the level of innovation between your nervous system and fat. Neurons connect to various kinds of body fat and can change the probability of its burning. By incorporating science-based tools, such as using cold, brown fat, beige fat, and neat, one can greatly accelerate the fat loss process.

    Foundational Steps for Optimal Health and Fat Loss

    To achieve the most out of any exercise or fat loss protocol, focus on getting the foundation of your health, hormones, and metabolism right. Quality and sufficient sleep, along with essential fatty acids from foods like fatty fish and grass-fed meats, can improve mood and metabolism while promoting good fat loss. To satisfy sugar cravings, try glutamine and amino acid-rich foods like cottage cheese. To support the thyroid system and metabolism, aim to get enough selenium by incorporating Brazil nuts into your diet. Making these small changes can help improve your overall health and position yourself for better fat loss results.

    The Power of Fermented Foods and Belief Effects on Gut Health and Fat Loss.

    Ingesting fermented foods daily can greatly assist in supporting the gut microbiome and thyroid hormone, as they are a good source of probiotics, iodine, and selenium. Moreover, belief effects also play a significant role in weight loss and fat loss. Simply being informed that movement and exercise can be beneficial for health can lead to enhanced fat and body loss. The power of belief can affect how we think, perform activities, and our physiology. A balanced approach lies between the hardcore metabolic science and belief effects, rooted in quality peer-reviewed science and physiology, that can leverage to increase the rates of fat loss.

    Using Thermogenesis to Accelerate Fat Loss

    Fat loss is heavily influenced by your thermogenic environment, which is controlled by your nervous system. While DNP is a highly fatal compound used by bodybuilders and athletes to lose weight, there are other ways to change the relationship between neurons and fat in your body to accelerate fat loss. This involves two processes - fat mobilization and fat oxidation. To mobilize fat, you need to break the backbone between glycerol and fatty acids. Thermogenesis is a leverage point that can significantly impact fat utilization, but it is often overlooked in favor of diet and exercise. Understanding the science behind fat utilization can help you effectively burn more fat.

    How Movement and Nervous System Activation Can Help Burn Fat

    To burn fat, you need to mobilize fat and then oxidize it to convert it into energy. This process is controlled by your nervous system, and movement is a powerful way to stimulate the release of adrenaline into fat, promoting more liberation and oxidation. Subtle movements like shivering can greatly increase fat loss, and it's not just induced by cold. Additionally, neuron-activating exercises like yoga and pilates can help activate the nervous system and mobilize fat. It's not just about calorie deficit but also about how you activate your nervous system to promote fat loss.

    Fidgeting can increase calorie burn and aid weight loss.

    Fidgeters burn anywhere between 800 to 2,500 calories more than the control group, and moving around a lot throughout the day greatly increases energy burn. This is a powerful way to increase calories burned, which can be especially beneficial for people who are already slightly overweight and averse to exercise. Fidgeting can lead to considerable weight loss, with studies showing a 20 to 30% increase in weight loss when incorporating fidgeting into weight loss goals. While exercise is important, increasing calorie burn through fidgeting can be a useful tool for those who are time-limited or not ready to embrace exercise. Even subtle movements can engage certain aspects of our musculature to burn more calories.

    How Subtle Movements Can Help You Burn Calories and Lose Fat

    Subtle movements such as fidgeting, standing up, walking around and pacing trigger epinephrine release from neurons and stimulate the mobilization and oxidation of fat, resulting in considerable calorie burn. This is referred to as Non-Exercise Activity Thermogenesis (NEAT) and can help offset excessive calorie intake and even contribute to fat loss. Shivering is another strong stimulus for fat loss through mobilization and oxidation of fatty acids. Cold exposure can increase metabolism and fat loss, but the protocol for doing so is often incorrect. Brown fat, which is rich in mitochondria, can convert food into energy and contribute to fat loss.

    How Cold Exposure can Help You Burn More Calories

    Cold exposure can increase brown fat thermogenesis and fat burning, leading to a stronger and hotter furnace that burns more calories. Shivering triggers the release of Ate S U C C I N a T E, a molecule that increases brown fat thermogenesis and fat burning. One to five times a week exposure to cold through cold shower or ice bath is beneficial for triggering the shiver-induced release of Ate S U C C I N a T E. Getting in and out of the cold without drying off can stimulate more shivering and increase the release of Ate S U C C I N a T E. However, it is important to get approval from a doctor before attempting cold exposure to avoid hypothermia and heart shock.

    Using Cold Exposure for Fat Loss and Beyond

    Cold exposure can accelerate fat loss, but it's important to find the right temperature and properly induce shivering. It's recommended to get in one to five times a week and not build up tolerance too quickly. A fat loss optimization protocol involves finding a temperature that induces shivering, then getting out after a minute and getting back in for one to three minutes while aiming to induce shivering again. It's important to access the shiver point to trigger brown fat thermogenesis and not just try to withstand the cold. Cold exposure can also promote resilience and reduce inflammation, but be cautious not to build up tolerance too fast.

    The Role of Brown Fat and Neurons in Thermogenesis and Fat Loss

    Brown fat is an important factor in regulating thermogenesis and metabolism, especially in infants. Exposure to cold environments can increase brown fat, leading to an increase in metabolism and fat loss. However, it is important to gradually increase exposure to cold and not become too adapted. Additionally, exercise timing and types can vastly improve fat loss. Neurons play a critical role in the control of white and brown adipose tissue, and neural innovation of white adipose tissue can help control lipolysis. While spot reduction was previously considered a myth, the issue remains interesting and requires further study.

    Exercise may trigger activation of neurons in specific fat pads for spot reduction.

    Spot reduction of fat may soon be possible using exercise that triggers the activation of neurons in specific fat pads. Engaging in novel types of movements during exercise may enhance the mobilization of stubborn body fat pads. Different types of exercise, including high intensity interval training (HIIT), sprint interval training (SIT), and moderate intensity continuous training (MICT), can have varying effects on hormones and metabolism, and should be chosen based on individual goals and preferences.

    How to Optimize Your Workout for Fitness and Weight Loss

    Interval training involving bursts of high intensity activity followed by recovery periods can be more effective than continuous moderate intensity training for fitness and weight loss. The ideal duration of high intensity bursts ranges from 60 to 240 seconds with sub-maximal efforts. Moderate intensity continuous training at 40-60% VO2 max or 55-70% max heart rate is another option for those looking for cardiovascular benefits. While fasted exercise may not specifically increase fat burning during short periods, research suggests that after 90 minutes of moderate intensity exercise, fasting beforehand can lead to increased fat oxidation. It is important to consider individual factors and goals when determining the most beneficial exercise regimen.

    Optimize Your Workouts for Fat Burning

    To burn more body fat during exercise, it's best to perform high intensity exercise for 20 to 60 minutes, followed by medium intensity exercise. If done fasted, the switch over point to burning body fat comes earlier. Insulin must be low for fat burning to occur, so fasting or consuming fats and proteins before exercise can be helpful. The duration of exercise doesn't matter as much as the intensity, but it's important to deplete glycogen before moving to steady state exercise. Overall, burning more fat during exercise is achievable with the right approach.

    The Optimal Exercise Routine for Fat Loss

    When it comes to fat loss, high intensity training followed by moderate to low intensity training is optimal because high intensity exercise burns more glycogen during the activity but post-exercise oxygen consumption goes up resulting in more fat oxidation. On the other hand, low to moderate intensity exercise leads to glycogen being burned after the exercise, which ultimately reduces fat oxidation. Therefore, exercising regularly with high intensity workouts, followed by low to moderate intensity training or simply going about your day, is beneficial for fat loss. This is because it increases your basal metabolic rate due to the way it engages the nervous system. It's important to pick exercises that you enjoy and can do regularly.

    Using Caffeine Safely and Effectively for Fat Burning and Exercise Enhancement

    Caffeine can be effective for burning fat by increasing the amount of epinephrine released, leading to increased fat oxidation. However, it should be ingested safely and within recommended dosages. Incorporating caffeine before exercise can enhance the amount of fat that one burns in any duration, and it can shift the percentage of fat oxidized compared to glycogen. Fidgeting alone can be great, but exercise is necessary for activating positive health effects of the cardiovascular system. Caffeine can be used as a supplement to increase fat loss, but it should not be relied on as a magic pill. It's essential to understand the science and prioritize behavioral tools before turning to supplements or extracts from diets.

    Mate and Gua tea can aid fat burning during exercise

    Drinking mate tea prior to exercise can increase fat burning and shift metabolism towards enhanced burning of fat. Mate tea triggers the ingestion of GLP one, which facilitates fat oxidation, and increases the percentage of fat burned during exercise. Pharmaceutical companies are developing drugs that utilize the GLP one pathway for the treatment of diabetes and obesity. However, prescription drugs should not be taken without the requirement of a doctor. It is possible to reuse mate tea leaves to extract more of the beneficial compounds increasing GLP one. Those seeking an alternative to mate tea may prefer gua tea, which is sweeter in taste and also triggers the GLP one pathway.

    Lowering Insulin and Increasing Fat Oxidation with Compounds and Diets.

    Reducing insulin can increase fat oxidation, and there are compounds such as burberine, Metformin, and carnitine that can aid in this process. It doesn't matter which diet you follow as long as you can adhere to it and keep insulin levels low. Lower or moderate carbohydrate diets tend to help with this. Monte and other compounds such as Ma Gua and GLP one can increase fat oxidation, but always be careful to explore these options with a prescription. Acetyl L carnitine can also aid in the conversion of fatty acids into ATP for increased fat loss. It's important to find an eating plan that is beneficial for your health and allows you to stick to the particular nutrition protocol.

    Benefits of Supplementing with L-Carnitine & Other Fat Loss Methods

    Supplementing with LCD L carnitine can offer a variety of positive effects on cellular metabolism, including reducing ammonia and C reactive protein levels, slightly lowering blood glucose and overall cholesterol levels, and improving fat oxidation rates. It has also been shown to reduce fatigue during exercise and lower inflammatory markers like interleukin six. Additionally, it has strong effects on rates of pregnancy and sperm quality. Although not necessary for fat loss, supplementing with acetyl L carnitine can help convert fatty acids into energy. Other methods for fat loss include increasing caloric burn through neat fidgeting, cold exposure, and exercise, as well as utilizing the GLP one pathway through the ingestion of certain compounds like ma or OSA.

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    Coleman Ruiz: Overcoming Physical & Emotional Challenges

    Coleman Ruiz: Overcoming Physical & Emotional Challenges
    In this episode, my guest is Coleman Ruiz, a former Tier One U.S. Navy SEAL joint task force commander. He served in Afghanistan and Iraq and as a BUD/S training officer. He shares his journey from childhood through the Naval Academy to elite Navy SEAL special operations. He shares the physical and emotional challenges he has overcome and discusses his struggle with post-traumatic stress disorder (PTSD). He also talks about the key role of mentors, family and friends in building resilience. Coleman gives us a raw, humble account of hitting rock bottom. He tells of the intense pain, fear, depression and suicidality in his journey of redemption. Coleman’s story is a real-life hero’s journey. He tells it with extraordinary vulnerability and humility. He explains the challenges and sudden tragedies that helped to ground, shape and renew him. His story will inspire listeners of all ages and backgrounds. Note: This conversation includes profanity and topics that are not suitable for all audiences and ages. For show notes, including additional resources, please visit hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman BetterHelp: https://betterhelp.com/huberman Maui Nui Venison: https://mauinuivension.com/huberman  Eight Sleep: https://eightsleep.com/huberman  Plunge: https://plunge.com/huberman Momentous: https://livemomentous.com/huberman Timestamps (00:00:00) Coleman Ruiz (00:01:55) Sponsors: BetterHelp, Maui Nui Venison & Eight Sleep (00:06:06) Childhood, “Wildness” (00:13:24) Wrestling, Combat Sports & Respect (00:22:26) Divorce, College Applications & Naval Academy (00:29:51) Sponsor: AG1 (00:31:22) Prep School, Patriotism, Fear (00:40:08) Growth Mindset, 24-Hour Horizon (00:43:02) Naval Academy, Mentor, Focus (00:52:45) Wife, Work Ethic (00:59:23) Sponsor: Plunge (01:00:51) Navy SEALs, BUD/S, Hell Week (01:04:51) BUD/S Success Predictors; Divorce & Aloneness; Rebellion (01:16:30) Patriotism, Navy SEALs, Green Team (01:22:15) Advanced Training, Tier One, Free-Fall (01:26:13) Special Operations, Deaths & Grief (01:36:08) Mentor Death & Facing Mortality (01:47:49) Warriors & Compassion; Trauma, Family (01:52:37) Civilian Life Adjustment (01:57:39) Hero With a Thousand Faces, Civilian Return & PTSD (02:07:03) Massage, Perspective, Space-Time Bridging (02:14:10) Psychedelics, Connection, Warrior Culture (02:19:15) Rock Bottom: Talk Therapy, Depression, Alcohol (02:25:50) Emotional & Physical Pain, Vulnerability, Fighter Mentality (02:30:42) Suicide, Asking For Help & Support (02:38:32) Therapy, PTSD Recovery, Dread; Pharmacology (02:44:54) Healing Process: Unsatisfaction & Asking For Help (02:54:03) Daily Routine, Movement, Nutrition (03:02:22) Manhood, Range, Parenthood, Surrender (03:10:08) Current Pursuits (03:16:01) Zero-Cost Support, Spotify & Apple Reviews, Sponsors, YouTube Feedback, Momentous, Social Media, Neural Network Newsletter Disclaimer
    Huberman Lab
    enApril 08, 2024

    Guest Series | Dr. Matthew Walker: The Biology of Sleep & Your Unique Sleep Needs

    Guest Series | Dr. Matthew Walker: The Biology of Sleep & Your Unique Sleep Needs
    In this episode 1 of a 6-part special series on sleep with Dr. Matthew Walker, Ph.D., professor of neuroscience and psychology and founder of the Center for Human Sleep Science at the University of California, Berkeley, and the author of the book “Why We Sleep” discusses the essential role that sleep plays in our health. We cover how sleep affects our hormones, immune system, learning and memory, mood, appetite, and weight regulation. We also discuss what causes the urge to sleep, how sleep is structured throughout the night, and the biology of the different phases of sleep. We also teach you how to determine your individualized sleep needs, including your chronotype (best waking and to-bed time), tips for combat snoring and insomnia, and your QQRT (Quality, Quantity, Regularity, and Timing)—a key framework for optimizing your sleep and therefore daytime energy and focus, and overall health. The next episode in this special series explores how to improve one’s sleep. For show notes, including referenced articles and additional resources, please visit hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Eight Sleep: https://eightsleep.com/huberman  BetterHelp: https://betterhelp.com/huberman  LMNT: https://drinklmnt.com/huberman  InsideTracker: https://insidetracker.com/huberman Momentous: https://livemomentous.com/huberman Timestamps (00:00:00) Importance of Sleep (00:02:24) Sponsors: Eight Sleep, BetterHelp & LMNT (00:06:00) Sleep; Non-REM & REM Sleep (00:11:40) Sleep Cycles, Individuality, Women vs. Men (00:14:49) Tool: Wakefulness in Bed, Insomnia (00:19:08) Non-REM Stages of Sleep (00:27:05) Role of Deep Sleep (00:34:02) Sponsor: AG1 (00:35:15) Light Sleep Stages, Hypnogogic Jerks (00:42:00) REM Sleep, Paralysis & Bizarre Dreams; “Falling” Asleep (00:49:09) Tools: Body Position & Sleep; Snoring & Sleep Apnea (00:57:43) Yawning & Theories, Contagion (01:04:03) Nodding Off, Afternoon & Postprandial Dip (01:08:46) Sponsor: InsideTracker (01:09:51) Sleep, Animals & Evolution (01:14:09) Poor Sleep & Health Consequences, Sleep Deprivation (01:27:13) Positive Effects of Good Sleep, Health Improvements (01:31:56) Sleep & Mood; Appetite & Weight Management (01:42:55) Sleep Deprivation & Looking Tired, “Beauty Sleep” (01:47:57) Tool: Getting Good Sleep, QQRT Macros, Quantity & Quality (01:56:45) Tool: Sleep Regularity, Mortality Risk (02:03:15) Tool: Sleep Timing, Chronotypes (02:14:21) Chronotypes & Insomnia, Circadian Rhythm, Shift Work (02:20:31) Tool: Sleep Tests, Alarm Clock, Micro-Sleeps (02:27:27) Sleep Inertia & Waking; Afternoon Dip, Optimum Performance (02:34:19) Causes of Sleep: Circadian Rhythm, Sleep Pressure (02:43:02) Adenosine & Sleepiness (02:46:13) Tool: Growth Hormone & Deep Sleep (02:50:47) Cortisol & Circadian Rhythm, “Tired But Wired” (02:57:24) Zero-Cost Support, Spotify & Apple Reviews, Sponsors, YouTube Feedback, Momentous, Social Media, Neural Network Newsletter Disclaimer
    Huberman Lab
    enApril 03, 2024

    Benefits & Risks of Peptide Therapeutics for Physical & Mental Health

    Benefits & Risks of Peptide Therapeutics for Physical & Mental Health
    In this episode, I explain the major categories and types of peptides currently in use for therapeutic purposes. I discuss peptides for improving tissue rejuvenation and repair, promoting longevity, improving muscle growth and fat loss, and boosting mood, vitality, and libido. I explain the biology of how these peptides work and both their potential benefits and risks. I also discuss peptide sourcing, dosages, cycling, routes of administration, and how peptides work in combination.  This episode will help you better understand the rapidly expanding landscape of peptide therapeutics and how to evaluate if specific peptides might be advantageous towards achieving your physical or mental health goals. For show notes, including referenced articles and additional resources, please visit hubermanlab.com. Use Ask Huberman Lab, our new AI-powered platform, for a summary, clips, and insights from this episode. Thank you to our sponsors AG1: https://drinkag1.com/huberman Mateína: https://drinkmateina.com/huberman Levels: https://levels.link/huberman Joovv: https://joovv.com/huberman LMNT: https://drinklmnt.com/huberman Momentous: https://livemomentous.com/huberman Timestamps (00:00:00) Peptides (00:03:20) Sponsors: Mateina, Levels & Joovv (00:07:44) What is a Peptide? (00:12:06) Peptide Sourcing, Lipopolysaccharide (LPS) (00:14:48) Rejuvenation & Tissue Repair: BPC-157, Angiogenesis (00:21:50) BPC-157 & Tissue Injury; Mode of Delivery (00:27:53) BPC-157: Safety, Doses, Cycling, Tumor Risk (00:35:16) Sponsor: AG1 (00:36:43) Tissue Repair: Thymosin Beta-4, TB-500 (00:40:49) Growth & Metabolism: Growth Hormone, IGF-1, Risks (00:45:25) Secretagogues, Sermorelin, Tesamorelin, CJC-1295 (00:52:21) Sponsor: LMNT (00:53:44) Ipamorelin, Hexarelin, GHRP-3, MK-677; Risks & Timing (00:58:69) Peptides for Growth Hormone & IGF-1, Risk; Combinations & Dosing (01:06:12) Longevity: Thymosin Beta-4, Epitalon (Epithalon) (01:12:09) Vitality: Melanotan, PT-141 (Vyleesi), Risks (01:17:21) Vitality: Kisspeptin (01:21:46) Peptides, Potential Benefits, Side-Effects & Risks (01:24:19) Zero-Cost Support, Spotify & Apple Reviews, Sponsors, YouTube Feedback, Momentous, Social Media, Neural Network Newsletter Disclaimer
    Huberman Lab
    enApril 01, 2024

    Asi Wind: What Magic & Mind Reading Reveal About the Brain

    Asi Wind: What Magic & Mind Reading Reveal About the Brain
    In this episode, my guest is Asi Wind. He's one of the world’s top magicians and mentalists.  We discuss what magic and mentalism reveal about the human mind, including how memories are made, how to erase them, and how and why we perceive things the way we do, all in the context of how he performs his astonishing tricks.  Asi explains that magic works because it involves storytelling, which is key to how we organize memories. He also explains how emotional connection allows people to co-create and believe a common narrative, even one that did not actually occur.  We also discuss how Asi's love of painting and photography and his specific daily routine allow him to access creativity. We also discuss fear, perfectionism, and how feeling emotions deeply serves his craft.  Whether you are interested in magic or not, this conversation with Asi will give you an incredible window into how you perceive, learn, and remember the world around you and how what you believe may or may not be based in reality.  For show notes, including referenced articles and additional resources, please visit hubermanlab.com. Use Ask Huberman Lab, our new AI-powered platform, for a summary, clips, and insights from this episode. Thank you to our sponsors AG1: https://drinkag1.com/huberman LMNT: https://drinklmnt.com/huberman  BetterHelp: https://betterhelp.com/huberman  AeroPress: https://aeropress.com/huberman  InsideTracker: https://insidetracker.com/huberman  Momentous: https://livemomentous.com/huberman Timestamps (00:00:00) Asi Wind (00:02:48) Sponsors: LMNT, BetterHelp & AeroPress (00:07:07) “Jazzy Magic”, Tricks & Improvisation, Memory (00:14:57) Magic & Imagination (00:24:06) Memory “Experiments” (00:29:18) Sponsor: AG1 (00:30:46) Reality Augmentation, Free Will (00:35:31) Audience Interactions & Connection, Empathy, Tool: Breathing (00:41:20) Audience, Empathetic Attunement & Connection; Skeptics (00:49:10) Trick Explanation, Props (00:57:21) Exposing Magic, Misdirection, Storytelling (01:07:29) Sponsor: InsideTracker (01:08:36) Delight, Hypnosis, Behavior Patterns (01:17:35) Hypnotists & Guiding Attention; Social Media (01:23:01) “Power of Pauses” & Memory; Tool: Gap Effects & Learning (01:30:14) Tension, Understanding Magic (01:36:16) Storytelling (01:43:00) Painting & Composition (01:51:08) Truths, Clean Slate, Art & Storytelling (01:59:03) Art & Motivation, Honesty (02:05:17) Inspiration & Creativity, “Sponge” (02:12:38) Morning Routine & Creativity (02:19:28) Memory & Fear, Power of Story; Tool: Walking & Creativity (02:29:53) Body Language (02:33:01) Perfectionism; Negative Emotions, Photography (02:40:19) Sensitivity, Empathy, Family (02:45:16) Incredibly Human Show (02:49:22) Zero-Cost Support, Spotify & Apple Reviews, Sponsors, YouTube Feedback, Momentous, Social Media, Neural Network Newsletter Disclaimer
    Huberman Lab
    enMarch 25, 2024

    LIVE EVENT Q&A: Dr. Andrew Huberman Question & Answer in Melbourne, AU

    LIVE EVENT Q&A: Dr. Andrew Huberman Question & Answer in Melbourne, AU
    Recently I had the pleasure of hosting a live event in Melbourne, AU. This event was part of a lecture series called The Brain Body Contract. My favorite part of the evening was the question and answer period, where I had the opportunity to answer questions from the attendees of each event. Included here is the Q&A from our event in Melbourne, AU at Plenary. Thank you to our sponsors AG1: https://drinkag1.com/huberman Eight Sleep: https://eightsleep.com/huberman Resources Ask Huberman Lab (AI platform) 10 Minute Non-Sleep Deep Rest (NSDR) Timestamps (00:00:00) Introduction (00:02:50) Strategies for Preventing Dementia (00:15:07) Enhancing Willpower: Is It Comparable to Muscle Training? (00:22:40) Minimizing Circadian Disruption for Shift Workers (00:29:24) Difference Between NSDR & Meditation (00:37:32) Combatting Mindless Phone Scrolling (00:42:18) Dream Clinical Trials (00:55:55) Conclusion Disclaimer
    Huberman Lab
    enMarch 22, 2024

    Dr. E.J. Chichilnisky: How the Brain Works, Curing Blindness & How to Navigate a Career Path

    Dr. E.J. Chichilnisky: How the Brain Works, Curing Blindness & How to Navigate a Career Path
    In this episode, my guest is Dr. E.J. Chichilnisky, Ph.D., a professor of neurosurgery and ophthalmology at Stanford University. He studies how we see and uses that information to build artificial eyes that restore vision to the blind.  We discuss how understanding the retina (the light-sensing brain tissue that lines the back of our eyes) is critical to knowing how our brain works more generally.  We discuss brain augmentation with biologically informed prostheses, robotics, and AI and what this means for medicine and humanity.  We also discuss E.J.’s unique journey into neuroscience and how changing fields multiple times, combined with some wandering, taught him how to guide his decision-making in all realms of life.  This episode ought to be of interest to anyone interested in learning how the brain works from a world-class neuroscientist, those interested in the future of brain therapeutics and people seeking inspiration and tools for navigating their own professional and life journey. For show notes, including referenced articles and additional resources, please visit hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Eight Sleep: https://eightsleep.com/huberman  ROKA: https://roka.com/huberman  BetterHelp: https://betterhelp.com/huberman  InsideTracker: https://insidetracker.com/huberman Momentous: https://livemomentous.com/huberman Timestamps (00:00:00) Dr. E.J. Chichilnisky (00:02:31) Sponsors: Eight Sleep, ROKA & BetterHelp (00:06:06) Vision & Brain; Retina (00:11:23) Retina & Visual Processing (00:18:37) Vision in Humans & Other Animals, Color (00:23:01) Studying the Human Retina (00:29:48) Sponsor: AG1 (00:31:16) Cell Types (00:36:00) Determining Cell Function in Retina (00:43:39) Retinal Cell Types & Stimuli (00:49:27) Retinal Prostheses, Implants (01:00:25) Artificial Retina, Augmenting Vision (01:06:05) Sponsor: InsideTracker (01:07:12) Neuroengineering, Neuroaugmentation & Specificity (01:17:01) Building a Smart Device, AI (01:20:02) Neural Prosthesis, Paralysis; Specificity (01:25:21) Neurodegeneration; Adult Neuroplasticity; Implant Specificity (01:34:00) Career Journey, Music & Dance, Neuroscience  (01:42:55) Self-Understanding, Coffee; Self-Love, Meditation & Yoga (01:47:50) Body Signals & Decisions; Beauty (01:57:49) Zero-Cost Support, Spotify & Apple Reviews, Sponsors, YouTube Feedback, Momentous, Social Media, Neural Network Newsletter Disclaimer
    Huberman Lab
    enMarch 18, 2024